Since it was first identified in 2003, bisphosphonate-induced osteonecrosis has come
under growing scrutiny by medical and dental specialists alike because it affects cancer
patients receiving intravenous bisphosphonate therapy and osteoporosis patients
receiving oral bisphosphonate therapy. Based on a clear understanding of the disease
mechanism and documented outcomes of the relatively small number of cases treated to date, this timely e-book presents definitive treatment protocols for patients who present at each stage in its progression. Equally important, it offers a simple method for predicting risk as well as crucial recommendations for steps that can be taken to prevent the disease from developing when bisphosphonate therapy is indicated.

Finally, a series of comprehensive case histories related to both oral and intravenous bisphosphonates provide direct guidance in managing patients spanning the full presentation spectrum.

Robert E. Marx, DDS
Professor of Surgery and Chief Division of Oral and Maxillofacial Surgery
Miller School of Medicine
University of Miami
Miami, Florida

Professor of surgery and chief of the Division of Oral and Maxillofacial Surgery, Miller School of Medicine, University of Miami, is a highly respected surgeon, researcher, and educator who has pioneered new concepts and treatments for pathologies of the oral and maxillofacial area as well as new techniques in major reconstructive surgery. He has made valuable contributions in the use of hyperbaric oxygen following radiation therapy; in the development of platelet-rich plasma; and in elucidating the relationship between smoking and carcinogenesis. For the past 30 years, he has trained scores of residents and fellows, many of whom have themselves established distinguished careers. He has published an impressive number of book chapters and journal articles; a textbook (with Diane Stern), Oral and Maxillofacial Pathology: A Rationale for Diagnosis and Treatment (Quintessence, 2003), which received the 2003 Award for Best Medical Book from the American Medical Writers Association; and a monograph (with Arun Garg), Dental and Craniofacial Applications of Platelet-Rich Plasma (Quintessence, 2005). He has received many other prestigious awards throughout his distinguished career as well, including the Harry S. Archer Award, the William J. Gies Award, the Paul Bert Award, and the Donald B. Osbon Award, all testaments to his dedication and commitment to the field of oral and maxillofacial surgery.